RGS1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11534
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | 1R20,B cell activation protein BL34,B-cell activation protein BL34,BL34,Early response protein 1R20,IER 1,IER1,Immediate early response 1 B cell specific,immediate-early response 1,B-cell specific,IR20,Regulator of G protein signalling 1,Regulator of G-protein signaling 1,RGS 1,RGS1,RGS1,RGS1抗体 |
| Swissprot | Q08116 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human RGS1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytosol,Plasma Membrane,extrinsic component of cytoplasmic side of Plasma Membrane |
| Tissue specificity | B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. |
客户发表文献
- 文献: RGS1 and related genes as potential targets for immunotherapy in cervical cancer: computational biology and experimental validation
样品类型: cervical cancer tissue,HeLa cell
