RIPK1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18284
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | Cell death protein RIP,FLJ39204,OTTHUMP00000039163,Receptor (TNFRSF) interacting serine threonine kinase 1,receptor interacting protein 1,Receptor interacting protein,Receptor interacting protein kinase 1,Receptor interacting serine threonine protein kinase 1,Receptor TNFRSF interacting serine threonine kinase 1,Receptor-interacting protein 1,Receptor-interacting serine/threonine-protein kinase 1,Rinp,RIP 1,RIP,Rip-1,RIP1,RIPK 1,Ripk1,RIPK1,Serine threonine protein kinase RIP,Serine/threonine-protein kinase RIP,RIPK1抗体 |
| Swissprot | Q13546 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Fusion protein of human RIPK1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:300; |
| Concentration | 0.7mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex. |
