ROCK1 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70124
宿主: Rabbit
反应性: M,R
应用: IHC
Overview
| Synonyms | coiled-coil-containing protein kinase 1,coiled-coil-containing protein kinase I,MGC131603,MGC43611,p160 Rhoassociated coiled coil-forming protein kinase,p160 ROCK-1,p160 ROCK1,p160ROCK,PRO0435,Renal carcinoma antigen NY REN 35,Renal carcinoma antigen NY-REN-35,Rho associated coiled coil containing protein kinase 1,Rho associated protein kinase 1,Rho kinase,Rho-alpha kinase,Rho-associated,Rho-associated protein kinase 1,ROCK I,ROCK-I,ROCK1,ROCK1,Rok,rokalpha,ROCK1抗体 |
| Swissprot | P70335,Q63644 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Rock1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:400 |
| Concentration | 300 μg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus membrane. Cell projection, bleb. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle. Associated with the mother centriole and an intercentriolar linker. Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers. Localizes at the cell membrane in an ITGB1BP1-dependent manner (By similarity). A small proportion is associated with Golgi membranes. |
| Tissue specificity | Highly expressed in brain, heart, lung, liver, stomach, spleen, kidney, testis, muscle, embryo and placenta.Highest expression level in aorta. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. |
