SFRP1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16059
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | Frizzled related protein 1,FRP 1,FRP,FRP-1,FRP1,FrzA,SARP 2,SARP-2,SARP2,Secreted apoptosis related protein 2,Secreted apoptosis-related protein 2,Secreted frizzled related protein 1,Secreted frizzled related protein,Secreted frizzled-related protein 1,SFRP 1,sFRP-1,SFRP1,SFRP1,SFRP1抗体 |
| Swissprot | Q8N474 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide of human SFRP1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:300 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted. Cell membrane or extracellular matrix-associated. Released by heparin-binding. |
| Tissue specificity | Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. |
