SH-PTP2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14341
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | BPTP3,CFC,JMML,METCDS,MGC14433,NS1,OTTHUMP00000166107,OTTHUMP00000166108,Protein tyrosine phosphatase 2,Protein tyrosine phosphatase 2C,Protein tyrosine phosphatase non receptor type 11,Protein-tyrosine phosphatase 1D,Protein-tyrosine phosphatase 2C,PTN11,PTP-1D,PTP-2C,PTP1D,PTP2C,PTPN11,SAP2,SH-PTP2,SH-PTP3,SH2 domain containing protein tyrosine phosphatase 2,SHP 2,SHP-2,Shp2,SHPTP2,SHPTP3,Syp,Tyrosine-protein phosphatase non-receptor type 11,PTPN11抗体 |
| Swissprot | Q06124 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human PTPN11 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:200-1:1000; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. |
| Tissue specificity | Widely expressed, with highest levels in heart, brain, and skeletal muscle. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. |
Images
Western Blot analysis of NIH/3T3 and hela cell using SH-PTP2 Polyclonal Antibody at dilution of 1:400
Immunohistochemistry of paraffin-embedded Human ovarian cancer using SH-PTP2 Polyclonal Antibody at dilution of 1:25
Immunohistochemistry of paraffin-embedded Human gastric cancer using SH-PTP2 Polyclonal Antibody at dilution of 1:25
