SIRT3 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70222
宿主: Rabbit
反应性: M
应用: WB
Overview
| Synonyms | hSIRT 3,hSIRT3,Mitochondrial nicotinamide adenine dinucleotide dependent deacetylase,NAD dependent deacetylase sirtuin 3 mitochondrial,NAD-dependent protein deacetylase sirtuin-3,mitochondrial,Regulatory protein SIR2 homolog 3,Silent mating type information regulation 2 S.cerevisiae homolog 3,Sir 2 like 3,SIR 2 like protein 3,SIR 3,SIR2 L3,Sir2 like 3,SIR2 like protein 3,SIR2-like protein 3,SIR2L3,SIR3,SIRT 3,SIRT3,Sirtuin 3,Sirtuin silent mating type information regulation 2 homolog 3 (S. cerevisiae),Sirtuin type 3,Sirtuin3,SIRT3抗体 |
| Swissprot | Q8R104 |
| Source | Rabbit |
| Reactivity | Mouse |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse SIRT3 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 500 μg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Mitochondrion matrix. |
| Tissue specificity | Strongly expressed in liver and kidney. Expressed in skeletal muscles (at protein level). Weakly expressed in lung.Highest expression level in proximal tubule. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. |
