SMARCA4 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15532
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | ATP dependent helicase SMARCA4,ATP-dependent helicase SMARCA4,BAF 190,BAF190,BAF190A,Brahma protein like 1,BRG1,BRG1 associated factor 190A,BRG1 protein,BRG1-associated factor 190A,BRM/SWI2 related gene 1,Global transcription activator homologous sequence,global transcription activator snf2l4,Homeotic gene regulator,hSNF2b,Mitotic growth and transcription activator,MRD16,Nuclear protein GRB1,Protein brahma homolog 1,Protein BRG-1,Protein BRG1,RTPS2,SMARC A4,SMARCA4,SMCA4,SNF2,SNF2 beta,SNF2 like 4,SNF2-beta,SNF2B,SNF2L4,SNF2LB,Sucrose nonfermenting like 4,SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 4,SWI/SNF related,matrix associated,actin dependent regulator of chromatin,subfamily a,member 4,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4,SWI2,Transcription activator BRG1,SMARCA4抗体 |
| Swissprot | P51532 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human SMARCA4 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Tissue specificity | Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. |
