SPACA3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52300
宿主: Rabbit
反应性: H
应用: IHC,ELISA
Overview
| Synonyms | 1700025M08Rik,ALLP17,Cancer/testis antigen 54,CT54,LYC3,Lysozyme like sperm specific secretory protein ALLP17,Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17,Lysozyme-like protein 3,LYZL3,processed form,SACA3,SLLP1,SPACA3,Sperm acrosome associated 3,Sperm acrosome membrane-associated protein 3,Sperm lysozyme-like protein 1,Sperm protein reactive with antisperm antibodies,Sperm protein reactive with ASA,SPACA3抗体 |
| Swissprot | Q8IXA5 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Full length fusion protein |
| Application | IHC(Detection kit: E-IR-R213),ELISA |
| Recommended dilution | IHC 1:30-1:150, ELISA 1:5000-1:10000 |
| Concentration | 1.5mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted and Cytoplasmic vesicle>secretory vesicle>acrosome membrane. Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | SPACA3 (sperm acrosome associated 3), also known as sperm lysozyme-like protein 1, lysozyme-like protein 3, lysozyme-like acrosomal sperm-specific secretory protein ALLP-17, cancer/testis antigen 54 (CT54), LYC3, SPRASA or LYZL3, is a 215 amino acid protein that participates in the fusion and adhesion of sperm and egg plasma membrane during fertilization. Identified as a novel cancer/testis antigen in hematologic malignancies, SPACA3 has the ability to elicit B-cell immune responses in patients with cancer and is considered a potential target for immunotherapy. A member of the glycosyl hydrolase 22 family which is expressed in testis, placenta and epididymis, SPACA3 exists as two alternatively spliced isoforms; SPACA3 isoform 1 is a single-pass type II membrane protein of the sperm acrosome whereas SPACA3 isoform 2 is a secreted protein. Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. |
