STAT1 Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22205
宿主: Mouse
反应性: H,M,R
应用: IHC-p
Overview
| Synonyms | Signal transducer and activator of transcription 1 91kD,CANDF7,DKFZp686B04100,IMD31A,IMD31B,IMD31C,ISGF 3,ISGF-3,OTTHUMP00000163552,OTTHUMP00000165046,OTTHUMP00000165047,OTTHUMP00000205845,Signal transducer and activator of transcription 1 91kDa,Signal transducer and activator of transcription 1,Signal transducer and activator of transcription 1,91kD,Signal transducer and activator of transcription 1-alpha/beta,STAT 1,Stat1,STAT1,STAT91,Transcription factor ISGF 3 components p91 p84,Transcription factor ISGF-3 components p91/p84,STAT1 Mouse (5H7)抗体 |
| Swissprot | P42224 |
| Source | Mouse |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic Peptide of STAT1 |
| Application | IHC-p(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-200 |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Translocated into the nucleus in response to IFN-gamma-induced tyrosine phosphorylation and dimerization. |
| Clone No | Clone:5H7 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4. |
| Background | Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. |
