STAT3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-32982
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC-p,IF
Overview
| Synonyms | 1110034C02Rik,Acute Phase Response Factor,Acute-phase response factor,ADMIO,APRF,AW109958,DNA binding protein APRF,FLJ20882,HIES,MGC16063,Signal transducer and activator of transcription 3 (acute phase response factor),Signal transducer and activator of transcription 3,STAT 3,Stat3,STAT3,Stat3抗体 |
| Swissprot | P40763 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from human Stat3 around the non-phosphorylation site of Ser727. |
| Application | WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213),IF |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:100-1:300;IF,,1:200-1:1000; |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1. |
| Tissue specificity | Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Background | Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. |
