STAT5A Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-13825
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | Mammary gland factor,MGF,Signal transducer and activator of transcription 5A,STA5A,STAT 5,STAT 5A,STAT5,STAT5A,STAT5A抗体 |
| Swissprot | P42229 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human STAT5A |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. |
Images
Western Blot analysis of Human fetal lung tissue using STAT5A Polyclonal Antibody at dilution of 1:450
Immunohistochemistry of paraffin-embedded Human thyroid cancer using STAT5A Polyclonal Antibody at dilution of 1:25
Immunohistochemistry of paraffin-embedded Human colon cancer using STAT5A Polyclonal Antibody at dilution of 1:25
