TAB3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11380
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | MAP3K7IP 3,Mitogen-activated protein kinase kinase kinase 7-interacting protein 3,NAP1,NF-kappa-B-activating protein 1,NFkB activating protein 1,TAB-3,Tab3,TAB3,TAK1 binding protein 3,TAK1-binding protein 3,TGF-beta-activated kinase 1 and MAP3K7-binding protein 3,TGF-beta-activated kinase 1-binding protein 3,TAB3抗体 |
| Swissprot | Q8N5C8 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human TAB3 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-1:5000; |
| Concentration | 0.2 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytosol,Endosome membrane,Extracellular region or secreted,extracellular exosome,Plasma Membrane |
| Tissue specificity | Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The product of this gene functions in the NF-kappaB signal transduction pathway.The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1.Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor.The human genome contains a related pseudogene. |
Images
Western Blot analysis of 293T, Raw264.7, NIH/3T3, K562 and Jurkat cell using TAB3 Polyclonal Antibody at dilution of 1:800
Immunohistochemistry of paraffin-embedded Human thyroid cancer using TAB3 Polyclonal Antibody at dilution of 1:25
Immunohistochemistry of paraffin-embedded Human brain using TAB3 Polyclonal Antibody at dilution of 1:25
