Tau Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22141
宿主: Mouse
反应性: H,M,R
应用: WB,IHC-p
Overview
| Synonyms | AI413597,AW045860,DDPAC,FLJ31424,FTDP 17,G protein beta1/gamma2 subunit interacting factor 1,MAPT,MAPTL,MGC134287,MGC138549,MGC156663,Microtubule associated protein tau,Microtubule associated protein tau isoform 4,Microtubule-associated protein tau,MSTD,Mtapt,MTBT1,MTBT2,Neurofibrillary tangle protein,Paired helical filament tau,Paired helical filament-tau,PHF tau,PHF-tau,PPND,PPP1R103,Protein phosphatase 1,regulatory subunit 103,pTau,RNPTAU,TAU,TAU,Tauopathy and respiratory failure,included,Tau Mouse (10E3)抗体 |
| Swissprot | P10636 |
| Source | Mouse |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic Peptide of Tau |
| Application | WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-2000;IHC,,1:100-200; |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Cytoplasm>cytosol. Cell membrane. Cytoplasm>cytoskeleton. Cell projection>axon. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. |
| Tissue specificity | Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. |
| Clone No | Clone:8A3 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Background | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
