TEK Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12907
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | Angiopoietin 1 receptor,Angiopoietin-1 receptor,CD202b,CD202b antigen,Endothelial tyrosine kinase,Endothelium specific receptor tyrosine kinase 2,hTIE 2,hTIE2,Hyk,p140 TEK,Soluble TIE2 variant 1,Soluble TIE2 variant 2,Tek,tek tyrosine kinase,TEK tyrosine kinase endothelial,tek tyrosine kinase,endothelial,TIE 2,TIE2,TIE2,Tunica interna endothelial cell kinase,Tyrosine kinase with Ig and EGF homology domains 2,Tyrosine kinase with Ig and EGF homology domains-2,Tyrosine protein kinase receptor TEK,Tyrosine protein kinase receptor TIE 2,Tyrosine-protein kinase receptor TEK,Tyrosine-protein kinase receptor TIE-2,Venous malformations multiple cutaneous and mucosal,VMCM 1,VMCM,VMCM1,TEK抗体 |
| Swissprot | Q02763 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide of human TEK |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Cell junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Secreted. Recruited to cell-cell contacts in quiescent endothelial cells. Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted. |
| Tissue specificity | Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma (at protein level). Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smootHuman, Mouseuscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. |
