TLR3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10066
宿主: Rabbit
反应性: H,M
应用: WB
Overview
| Synonyms | CD283,CD283 antigen,IIAE2,TLR 3,Tlr3,TLR3,Toll Like Receptor 3,Toll-like receptor 3,TLR3抗体 |
| Swissprot | O15455 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human TLR3 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Endoplasmic reticulum membrane. Endosome membrane. |
| Tissue specificity | Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity.TLRs are highly conserved from Drosophila to humans and share structural and functional similarities.They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.The various TLRs exhibit different patterns of expression.This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes.It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons.It may thus play a role in host defense against viruses.Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. |
