TMEFF2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-13737
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | Cancer/testis antigen family 120 member 2,CT120.2,HPP 1,HPP1,Hyperplastic polyposis protein 1,TEFF 2,TEFF2,TEFF2,TENB 2,TENB2,TMEFF2,Tomoregulin,Tomoregulin-2,TPEF,TR 2,TR,TR-2,Transmembrane protein containing epidermal growth factor and follistatin domains,Transmembrane protein TENB2,Transmembrane protein with EGF like and two follistatin like domains 2,Transmembrane protein with EGF-like and two follistatin-like domains,TMEFF2抗体 |
| Swissprot | Q9UIK5 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide of human TMEFF2 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:25-1:100 |
| Concentration | 1.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted and Membrane. |
| Tissue specificity | Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | TMEFF2 (transmembrane protein with EGF-like and two follistatin-like domains 2), a gene encoding a plasma membrane protein with two follistatin-like domains and one epidermal growth factor–like domain, had limited normal tissue distribution and was highly overexpressed in prostate cancer.The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. |
