TPM1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14422
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | AA986836,AI854628,Alpha tropomyosin,alpha-TM,Alpha-tropomyosin,C15orf13,cardiomyopathy,hypertrophic 3,CMD1Y,CMH3,HTM alpha,HTM-alpha,OTTHUMP00000163688,sarcomeric tropomyosin kappa,TM2,Tmpa,TMSA,Tpm-1,TPM1,TPM1,tropomyosin 1 (alpha),tropomyosin 1 (alpha) isoform 1,tropomyosin 1 (alpha) isoform 2,tropomyosin 1 (alpha) isoform 3,tropomyosin 1 (alpha) isoform 4,tropomyosin 1 (alpha) isoform 5,tropomyosin 1 (alpha) isoform 6,tropomyosin 1 (alpha) isoform 7,Tropomyosin 1,Tropomyosin alpha 1 chain,Tropomyosin alpha-1 chain,Tropomyosin,skeletal muscle alpha,Tropomyosin-1,TPM1抗体 |
| Swissprot | P09493 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human TPM1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-1:5000;IHC,,1:50-1:200; |
| Concentration | 0.2 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytoskeleton. |
| Tissue specificity | Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells.Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil.It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments.The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction.In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described.Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. |
Images
Western Blot analysis of Mouse heart tissue using TPM1 Polyclonal Antibody at dilution of 1:1000
Immunohistochemistry of paraffin-embedded Human breast cancer using TPM1 Polyclonal Antibody at dilution of 1:80
Immunohistochemistry of paraffin-embedded Human gastric cancer using TPM1 Polyclonal Antibody at dilution of 1:80
