ZAP70 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19063
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | 70 kDa zeta associated protein,70 kDa zeta-associated protein,EC 2.7.10.2,FLJ17670,FLJ17679,Selective T cell defect,SRK,STD,Syk related tyrosine kinase,Syk-related tyrosine kinase,Truncated ZAP kinase,Tyrosine protein kinase ZAP70,Tyrosine-protein kinase ZAP-70,TZK,ZAP 70,ZAP70,ZAP70,Zeta chain associated protein kinase 70kD,Zeta chain associated protein kinase 70kDa,Zeta chain associated protein kinase 70kDa isoform 1,Zeta chain associated protein kinase 70kDa isoform 2,Zeta chain of T cell receptor associated protein kinase 70,Zeta chain TCR associated protein kinase 70kD,Zeta chain TCR associated protein kinase 70kDa,ZAP70抗体 |
| Swissprot | P43403 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ZAP70 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:300; |
| Concentration | 0.96mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Cell membrane. After antigen stimulation, isoform 1 concentrates at the immunological synapse and isoform 2 remains cytoplasmic. Co-localizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Zeta-associated protein (ZAP)-70,a member of the Syk family of tyrosine kinases,plays an important role in T-cell receptor signaling,natural killer (NK) cell activation and early B-cell development. ZAP-70 is expressed in a subset of cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with unmutated immunoglobulin heavy-chain variable region (IgVH) genes and is associated with poor clinical outcome. |
